Although clear immunological signals of efficacy or incidence of secondary autoimmunity were not identified, exploratory random GEE Poisson analyses support the possibility that the relative balance of several key potentially pathogenic and regulatory subsets is associated with the risk for or protection from inflammatory Gd+ lesions, while the risk for T2 lesions is associated with CD3+CD8+CXCR3+ T cells. This evidence concerns the gene CD8A and Autoimmunity.