In addition, the Th2 cytokines GRO-α and eotaxin were well controlled by the Th1 cytokines MCP-1, IFN-γ and IL-8 in the healthy control group, whereas GRO-α and eotaxin levels were poorly controlled by Th1 cytokines in the AE patient group, confirming the presence of an inflammatory response in AE patients. This evidence concerns the gene CXCL8 and acrodermatitis enteropathica.