Consistent with the cooperative action between SIRT1 and SIRT6, independent studies have revealed an interaction between SIRT1 and SIRT7, showing that SIRT1 recruits SIRT7 to promote cancer cell metastasis (Malik et al., 2015), and that SIRT1 and SIRT7 antagonistically regulate adipogenesis (Fang et al., 2017). Here, SIRT6 is linked to cancer.