Intriguingly, it has also been reported that GluK2 internalization following SUMOylation promotes binding to mixed lineage kinase 3 (MLK3) and activation of the MLK3‐c‐Jun N‐terminal kinase 3 (JNK3) pathway, which could contribute to neuronal loss in ischemia (Zhu, Xu, Du, & Hou, 2012). The gene discussed is MAP3K11; the disease is ischemia.