Yin et al. compared a LMWH and adriamycin combined therapy to adriamycin alone, and found that the combined therapy decreased the lung metastasis of breast cancer cells in C3 H mice, and that heparin inhibited vascular endothelial growth factor (VEGF) expression in tumor tissue and induced cancer cell apoptosis [31]. The gene discussed is VEGFA; the disease is neoplasm.