Consequently, serum exo‐miR‐1269a (AUROC = 0.837) and exo‐miR‐4661 (AUROC = 0.924) showed significantly greater accuracy than serum AFP (AUROC = 0.604) in diagnosing early‐stage HCC among the patients with CH or LC. This evidence concerns the gene AFP and cyclic hematopoiesis.