In diagnosing HCC among the patients with CH and LC, serum exo‐miR‐25‐3p, miR‐1269a, and miR‐4661‐5p showed significantly greater AUROC values (0.690, 0.829, and 0.910, respectively) than serum AFP (0.597). The gene discussed is AFP; the disease is hepatocellular carcinoma.