For distinguishing mUICC stage I/II stage HCC from patients with CH or LC, serum exo‐miR‐1269a and 4661‐5p also showed greater AUROC value than serum AFP (AUROC; miR4661‐5p = 0.910, miR‐1269a 0.583, AFP = 0.540; Figure 5B). This evidence concerns the gene AFP and cyclic hematopoiesis.