In diagnosing HCC among the patients with CH and LC, serum exo‐miR‐25‐3p, miR‐1269a, and miR‐4661‐5p showed significantly greater AUROC values (0.690, 0.829, and 0.910, respectively) than serum AFP (0.597). This evidence concerns the gene AFP and cyclic hematopoiesis.