Previous studies investigated the potential value of first‐trimester maternal serum markers of GDM reported promising results, such as insulin resistance (sex hormone‐binding globulin and homeostasis model assessment index), inflammation (high sensitive C‐reactive protein), and adipocytokines (adiponectin, visfatin, and leptin) which have been measured in the first or second trimester of GDM.11, 12, 13, 14, 15. This evidence concerns the gene ADIPOQ and gestational diabetes.