Recently, Mavreli et al18 using proteomic analyses identified overexpression of prenylcysteine oxidase 1 (PCYOX1), beta‐ala‐his dipeptidase (CNDP1), extracellular matrix protein 1 (ECM1), basement membrane‐specific heparan sulfate proteoglycan core protein (HSPG2), and thrombospondin 4 (TSP‐4) in the 1st‐trimester maternal plasma of women who were subsequently diagnosed with GDM followed by confirmatory ELISA. The gene discussed is CNDP1; the disease is gestational diabetes.