Finally, postnatal injection with 7,8-DHF in a mouse model of Down syndrome rescued dendritic spine number and levels of the presynaptic protein synaptophysin (Stagni et al. 2017) and was able to ameliorate the TrkB/p75NTR imbalance, seen in Huntington’s disease (Garcia-Diaz Barriga et al. 2017). This evidence concerns the gene NTRK2 and juvenile Huntington disease.