Intriguingly, the cognitive impairment as well as the decrease in spine number could be rescued by a treatment with the TrkB agonist 7,8-sihydroxyflavone (7,8-DHF; Zeng et al. 2012b) strengthening the link between BDNF/TrkB signaling and spine loss upon aging. The gene discussed is BDNF; the disease is Cognitive impairment.