Finally, there is clear evidence that elevated levels of vWF are a predictive factor for ischemic heart disease, cardiovascular mortality and stroke in healthy individuals (Folsom et al. 1999; Jager et al. 1999; Rumley et al. 1999), and iCAM for myocardial infarction (Ridker et al. 1998). This evidence concerns the gene VWF and stroke disorder.