COPZ1 and cancer: The gene expression and DNA copy number of the hub gene in HCC were obtained through the Oncomine 4.5 database, and data with high reliability were selected (P<0.05).The gene expression and DNA copy number of COPZ1 and EFTUD2 were significantly higher in liver cancer tissues than in normal tissues, and the Over-expression Gene Rank and DNA Copy Number Gain Gene Rank of all gene expressions are in the top 30% (Figure 10).The DNA methylation status of COPZ1 and EFTUD2 obtained from DiseaseMeth 2.0 in normal tissues was higher than that in cancer tissues (Supplementary Figure S5).