The gene expression and DNA copy number of the hub gene in HCC were obtained through the Oncomine 4.5 database, and data with high reliability were selected (P<0.05).The gene expression and DNA copy number of COPZ1 and EFTUD2 were significantly higher in liver cancer tissues than in normal tissues, and the Over-expression Gene Rank and DNA Copy Number Gain Gene Rank of all gene expressions are in the top 30% (Figure 10).The DNA methylation status of COPZ1 and EFTUD2 obtained from DiseaseMeth 2.0 in normal tissues was higher than that in cancer tissues (Supplementary Figure S5). This evidence concerns the gene EFTUD2 and hepatocellular carcinoma.