INS and obesity due to melanocortin 4 receptor deficiency: Interestingly, serum SOST levels were found to be positively correlated with abdominal and gonadal fat, as well as with biochemical markers related to metabolic disease in postmenopausal women.60 Additionally, SOST knockout or antibody treatment results in reduced adipose tissue accumulation, which is associated with increased insulin sensitivity and improved metabolic parameters.61 This indicates that Wnt inhibitors are influenced by obesity and may have endocrine functions between adipose tissue and the skeleton.