The result suggests that SYK is critically involved in the exacerbation of alveolar bone resorption in Sh3bp2KI/+ mice, and provides another piece of evidence that SYK is a critical downstream kinase of SH3BP2 in myeloid cells.3 We administered a novel SYK inhibitor GS‐99738 intraperitoneally starting from 1 day before periodontitis induction. This evidence concerns the gene SH3BP2 and periodontitis.