We found that 200 mg/kg GS‐9973 reduces alveolar bone loss in female Sh3bp2KI/+ mice, but not in males, with periodontitis (Supplemental Fig. S8), suggesting that SYK activation is more critical in female Sh3bp2KI/+ osteoclasts to regulate bone resorption in ligature‐induced periodontitis. Here, SYK is linked to periodontitis.