Pedersen et al. also proved that patients with diabetes mellitus type II with clinical complication such as cardiovascular disease and obesity had higher concentration of plasma calprotectin than the general population; they also described a positive correlation between the level of calprotectin BMI, triglycerides, hs-CRP, insulin, and negative correlation with HDL cholesterol, etc. [18]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.