Obesity has been shown to promote expansion of Th17 cells and IL-17 production in adipose tissue; atherosclerosis is defined as a chronic inflammatory process with endothelial dysfunction, deposits of lipids, and macrophages in the arterial walls; moreover, it has been reported that Th17 and IL-17A are involved in the progression of atherosclerosis. The gene discussed is IL17A; the disease is endothelial dysfunction.