As shown in the heatmap (Figure 5C) where red region indicated the activation of corresponding pathways, we could observe both the up-regulation of several cancer related processes like hypoxia, epithelial mesenchymal transition, angiogenesis or PI3K-AKT-MTOR signaling, and immune-related pathway including interferon (IFN) γ response or complement cascade. Here, AKT1 is linked to cancer.