DLL-3 is a member of the Notch ligand family that is aberrantly expressed on the cell surface of Small cell lung cancer (SCLC), Merkel cell Carcinoma (MCC) (96) and other neuroendocrine tumor cells (96–99) making it an attractive therapeutic target in NECs as proposed at latest international conferences, including AACR (96) and ESMO 2019 (100) annual meetings (96) and tested in ongoing trials on SCLC (TAOHE, NCT0306181). The gene discussed is DLL3; the disease is small cell lung carcinoma.