The definitions of the variables in the JNK and NF-κB pathways are included in electronic supplementary material, Appendices B and C. In summary, π function πact,   MM JNK_PP and 24 ODEs are new additions to our model, allowing us to investigate the essential role of the interactions between NF-κB and JNK signalling in the development of MM. Here, MAPK8 is linked to Miyoshi myopathy.