While the three-dimensional structure of the human LOX protein has not been resolved so far, it furthermore needs to be explored which isoforms of LOX are relevant in the context of AML and whether its regulation through HIFs in hypoxia, its ability to recruit CD11b myeloid cells which adhere to crosslinked collagen and produce matrix-metalloproteinase-2 enhancing premetastatic niche formation is of relevance in AML. The gene discussed is LOX; the disease is acute myeloid leukemia.