The top aging marker (RBMS1) played a vital role in cell apoptosis [17]; the most notable PD risk biomarker (ADD2) revealed the importance of the mitochondrial Ca2+ imbanlance; and the most important network node SLC37A1 also indicated the mitochondria-related mechanisms of PD through the energy metabolism. The gene discussed is RBMS1; the disease is late-onset Parkinson disease.