GPT and acute myeloid leukemia: A first-in-human Phase I trial of APR-246 included seven patients with refractory AML and demonstrated that the drug was well-tolerated with DLTs of increased alanine aminotransferase (ALT)/aspartate aminotransferase (AST), dizziness, confusion, and sensory disturbances and had a favorable pharmacokinetic (PK) profile (Lehmann et al., 2012).