CD47 and acute myeloid leukemia: The discoveries that CD47 is overexpressed on AML cells, that its increased expression is an independent poor prognostic factor, and that inhibitory antibodies can successfully enable phagocytosis of leukemic cells and initiate an antitumor T-cell response, led to the further investigation of CD47 as a therapeutic target (Jaiswal et al., 2009; Majeti et al., 2009; Tseng et al., 2013; Liu et al., 2015).