Moreover, the level of human HPV16-specific CD8+ Tscm (CD8+tet+CD45RA+CD62L+CD95+CD122+) in HPV16 infected patients without tumor, was higher than that of cancer patients (Figures 6C,D), indicating that HPV16-specific Tscm cells might prevent the HPV infection to move on to the development of cervical cancer. This evidence concerns the gene IL2RB and cancer.