Nrf2 dysfunction or reduced Nrf2 activity has been found in certain oxidative stress-associated conditions such as aging-related vascular inflammation (Usatyuk and Natarajan, 2004; Ungvari et al., 2011b), obesity-induced neurovascular dysfunction (Tarantini et al., 2018), and the disturbed flow-mediated atheroprone regions of the vasculature (Mcsweeney et al., 2016). This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.