PTK2B and arthritic joint disease: Other studies report the peripheral use of genistein, related agents and isoflavones have local anti-inflammatory activity (by PTK inhibition) in vitro and in animal models, including arthritis (Orlicek et al., 1999; Verdrengh et al., 2003; Dijsselbloem et al., 2004; McNearney et al., 2010; Mohammad-Shahi et al., 2011; Li et al., 2014; Liu et al., 2019).