Furthermore, Portulaca oleracea L. Polysaccharide (POL-P3b) could inhibit the expression of TLR4, MyD88, TRAF6, AP-1, and NF-κB subunit P65 in HeLa cells, thereby inhibiting the TLR4/NF-κB pathway to induce Cervical cancer cells apoptosis (Zhao R. et al., 2017). Here, NFKB1 is linked to cervical cancer.