Speca et al. (2016) and Di Gregorio et al. (2017) demonstrated that the specific anti-fibrotic property of GED-0507-34 Levo, a 5-ASA analogue, depends on the specific activation of PPARγ and was able to ameliorate intestinal fibrosis in the DSS-induced colitis model. The gene discussed is PPARG; the disease is colitis.