PPARA and osteoporosis: Additionally, the development of new compounds as therapies that could interact, directly or indirectly, on the PPAR pathway would avoid the use of corticosteroid therapies and their known side effects, including osteoporosis, aseptic joint necrosis, adrenal insufficiency, gastrointestinal, hepatic, and ophthalmologic effects, hyperlipidemia, growth suppression, and possible congenital malformations.