PPARG and obesity due to melanocortin 4 receptor deficiency: Though it is unknown whether the anti-inflammatory properties of exercise prevent colonic inflammation in obesity (Gleeson et al., 2011), some studies have reported that exercise may induce the generation of PPARγ ligands in the plasma, which are capable of activating PPARγ signaling within monocytes and contributing to anti‐inflammatory processes (Thomas et al., 2012).