APP and Alzheimer disease: Our work demonstrated that seizures induce ΔFosB accumulation in the hippocampus of two mouse models with spontaneous recurrent seizures: pilocarpine-treated mice (Pilo mice) as well as transgenic mice that express human amyloid precursor protein (APP) carrying mutations linked to AD (line J20) (Corbett et al., 2017; You et al., 2017; Fu et al., 2019).