We found that many ΔFosB target genes are uniquely bound in APP mice or in Pilo mice, but each set of unique target genes (and the target genes that APP and Pilo mice share) contained some genes that are implicated in neurodegenerative diseases and/or epileptogenesis, and many genes that represent similar functional categories relevant to conditions with seizure activity (see Table 1). Here, APP is linked to neurodegenerative disease.