HMGB1 and melanoma: Lee et al. demonstrated that HMGB1 depletion causes a senescence-apoptosis shift in B16-F10 melanoma cells (Lee et al., 2019[6]), consistently, our study indicated that down-regulation of HMGB1 expression promotes ALO-induced A375 cell apoptosis, whereas up-regulation of HMGB1 expression inhibits ALO-induced A375 cell apoptosis.