For CRC patients, PTPN3, PTPN7, PTPN11, PTPN12, PTPN13 and PTPN14 were upregulated while PTPN2, PTPN18, PTPN21, and PTPN22 expressions were downregulated according to Oncomine. The gene discussed is PTPN21; the disease is colorectal carcinoma.