PLK4 and cancer: In addition, taxanes can impair microtubule functions to kill cancer cells or inhibit the proliferation of cancer cells, γ-Tubulin is believed to participate in microtubule nucleation by forming a multiprotein ring complex (γ-TuRC), and PLK4 is an upstream regulator for γ-tubulin, which is dependent on format of the γ-tubulin-containing structure, suggesting the possible involvement of PLK4 in chemo-resistance [41].