As shown in Fig. 5c, ADAM9, ARHGAP42, DDX60, EFNB2, ERAP2, GMNN, KYNU, OAS1 and SERTAD4 were up-regulated while DMD, DTNA, ING5, MTCP1 and TRIM52 were down-regulated in PAAD (Fig. 5d). The gene discussed is EFNB2; the disease is pancreatic adenocarcinoma.