ARHGAP30 overexpression significantly decreased pancreatic cancer cell proliferation and metastasis; increased apoptosis; reduced β-catenin, B-cell lymphoma 2 (Bcl-2), MMP2, and MMP9 expression; and increased Bcl-2-associated X protein (Bax) and cleaved caspase-3 expression. The gene discussed is CASP3; the disease is pancreatic neoplasm.