Amongst splice factors, hypoxia also induces alternative splicing of the ubiquitous splicing factor YT521 (YTHDC1), switching expression to two non-coding YT521 variants 2 and 3 mRNAs, functionally coupled to nonsense mediated decay, that impact the splicing of cancer-associated BRCA2 and PGR [64]. Here, YTHDC1 is linked to cancer.