Hypoxia induced oncogenic alternative spliced RON isoforms associate with breast, lung, liver, kidney, bladder, ovarian, colon, pancreatic, gastric and prostate carcinoma progression and, in contrast to dominant negative RON isoforms, in general, promote EMT, tumour cell migration, scattering, invasion and metastatic progression (Fig. 5a )[99]. Here, MST1R is linked to prostate carcinoma.