Hypoxia also increases endothelial cell expression of the splice factor NOVA2, which is overexpressed in colon and ovarian cancers, and regulates endothelial cell polarity, vascular lumen formation, and also promotes expression of a soluble L1-ΔTM L1CAM alternative splice isoform, which stimulates angiogenesis and promotes ovarian cancer progression [147, 148]. Here, NOVA2 is linked to ovarian carcinoma.