FN1 and cancer: Hypoxia-induced alternative splicing has also been implicated in tumor-induced lymphangiogenesis in mouse xenografts, inducing the expression of the alternative extra domain A fibronectin (EDA-FN) isoform that increases lymphangiogenesis by promoting VEGFC expression, and also promotes stem cell proliferation [153, 154], implicating hypoxia-induced alternative EDA-FN splicing in lymphatic metastatic dissemination and cancer stemness (Fig. 3a).