This has been demonstrated by down regulating VEGFA expression in a human tumour mouse xenograft model, resulting in the pruning immature permeable vessels, re-modeling a less-permeable, less-tortuous vasculature with more pericytes and near-normal basement membrane, responsible for increasing tumour oxygenation, decreasing tumour interstitial pressure and improving drug penetration [243]. Here, VEGFA is linked to neoplasm.