The ubiquitin proteasome pathway inhibitor Bortezomib reduces the proliferation CA46 and Daudi Burkitt lymphoma cells by down regulating the expression of high molecular weight sumoylated hnRNP K splicing factor and cMyc and up-regulating the expression of low molecular weight de-sumoylated hnRNP K, implicating sumoylated hnRNP K and cMyc repression in Bortezomib inhibition of Burkitt Lymphoma cell proliferation [320]. The gene discussed is SLU7; the disease is Burkitt lymphoma.