Therapeutic strategies for the inhibition of the hypoxia-promoted TrkAIII oncogene, a potential driver oncogene in cancers including neuroblastoma and Merkel cell carcinoma, include the small molecule Trk tyrosine kinase inhibitors, Larotrectinib, Entrectinib, Cabozantinib, Merestinib, TRS-011, DS-6051B, MGCD156, PLX486 and DCC-2710, FDA-approved or in clinical trials for cancers with Trk-fusion oncogenes or with altered Trk activity, that could be repurposed for treating tumours that express TrkAIII (Fig. 6b) [328]. The gene discussed is NTRK1; the disease is Merkel cell skin cancer.