EGFR and neoplasm: Hypoxia also promotes aberrant/alternative splicing of the epithelial growth factor receptor EGFR, resulting in expression of the constitutively active, exon 2–7 skipped EGFRvIII (ΔEx 2–7) isoform, a proliferation promoting driver-oncogene in several tumour-types, including glioblastoma multiforme [93–95], and also induces pro-proliferation Erb4 signaling in mammary epithelial cells [96].