In breast cancer cells, hypoxia-sensitive hnRNPs also induce alternative Mcl1 splicing [170], lncRNA LUCAT-1 expression, LUCAT-1 complexing with PTPB1 splice factor promoting survival and therapeutic-resistance [100] and alternative intron retention splicing and NMD inactivation of TP53, resulting in evasion of TP53 and BAX-dependent apoptosis [56]. Here, LUCAT1 is linked to breast cancer.