PTBP1 and cancer: Hypoxia also suppresses the expression exon 3 and 4 skipped Mushash-1 RNA binding protein in cancer cells, enhancing survival and resistance to cisplatin cytotoxicity [173], and the atypical splicing factor SRSF10 also plays a central role in promoting the expression of alternatively spliced stress- and apoptosis-associated genes, promoting survival under ER-stress conditions (Fig. 3b) [174].