Hypoxia reduces the KRAS 4A to 4B (exon 4a skipped) alternative splice ratio, helping to explain predominant mutation-activated KRAS4B splice variant oncogene expression in colon tumours and cancer stem cells [36, 97, 98], and induces predominant short form MXIs alternative splicing reducing MIX1 antagonism of Nmyc-dependent proliferation of relevance to aggressive autonomous Nmyc amplified neuroblastoma growth [57]. The gene discussed is MYCN; the disease is neuroblastoma.