NFYA and neuroblastoma: Doxorubicin also induces alternative splicing of the NF-YA component of the heterotrimeric ubiquitous transcription factor NF-Y in human neuroblastoma cells, resulting in expression of a cytotoxic NF-YAx exon 3 and exon 5 skipped isoform that, upon overexpression, induces neuroblastoma cell autophagic necroptosis [92].