Receptor tyrosine kinase proto-oncogenes [87] that interact with the hypoxic tumour microenvironment [88], resulting in oncogenic activation, include the neurotrophin tropomyosin-related tyrosine kinase receptor TrkA that exhibits hypoxia-induced oncogenic alternative TrkAIII splicing in human neuroblastoma, pheochromocytoma, leukemia and medullary thyroid cancer cells. This evidence concerns the gene NTRK1 and hereditary pheochromocytoma-paraganglioma.