Under an additive model, the data provide support for a model in which decreasing G6PD activity (estimated by rs1050828 genotype) only increased the risk of pneumococcal bacteremia during the pre-decline period (ORPre-decline = 1.41, 95% CI 1.01–1.97, PPre-decline = 0.044). Here, G6PD is linked to pneumococcal bacteremia.