APPSweCCR2−/− mice show higher Aβ deposition around blood vessels and rapid cognitive decline than APPSweCCR2+/+, which suggests that CCR2 deficiency significantly impaired Aβ clearance and amplified vascular Aβ deposition.34 By contrast, memory capacities could be restored after transplanting of wild-type bone marrow stem cells.35 This suggests that the clearing of Aβ promoted by BMDM may occur in a CCR2-dependent manner. Here, CCR2 is linked to Mental deterioration.