ABCA7 and Alzheimer disease: ATP-binding cassette transporter A7 (ABCA7) is a genetic risk factor for late-onset AD.42 Researchers crossed ABCA7-deficient mice with J20 amyloidogenic mice, through which they discovered ABCA7 loss doubled insoluble Aβ levels in the brain.43 Their study showed that bone marrow–derived macrophages derived from ABCA7-deficient mice had a 51% reduction in the ability to take up oligomeric Aβ compared to wild-type mice.43