Stromal-derived factor 1α, an effective chemoattractant for hematopoietic progenitor cells, might participate in the migration of BMDM from peripheral cycle to brain, therefore providing a promising target for the treatment of AD.54 A research was conducted to explore the function of the combined use of granulocyte colony-stimulating factor (G-CSF), AMD3100 (CXCR4 antagonist), and SDF-1α. The gene discussed is CSF3; the disease is Alzheimer disease.