In Croatian patients with allergic diseases including atopic dermatitis, allergic rhinitis, asthma, and allergic contact dermatitis, low frequencies of FLG null mutations (R501X, 2282del4, R2447X, and S3247X) were detected; however, this study showed an association of FLG null mutations with other skin disorders [33]. The gene discussed is FLG; the disease is allergic contact dermatitis.