We also noticed that IDH‐mutant or IDH‐like LIHC and PRAD samples belonged to subtypes with low ESR1 expression, while high ESR1 subtype was exclusively IDH‐wild‐type in glioma (GBM and LGG), and the expression of ESR1 was lower in IDH1 mutated samples (Figure S6). The gene discussed is ESR1; the disease is central nervous system cancer.