Out of 18, seven proteins were quantified in early but not in advanced ADC samples (ARAP1, ZFR, EDC3, HMOX2, NT5C3A, PRPS2,and ICAM3; referred as ON/OFF in Table 2) and 11 proteins were overexpressed in early‐stage ADC (MCM6, SNRNP70, CDC5L, RBM12, RBM17, S100A14, THUMPD1, MX1, UBE2H, PXDN, and SPR; adj. The gene discussed is ZFR; the disease is AIDS dementia complex.