Several studies have demonstrated that SOCS family proteins are modulators of cytokine and growth factor signalling whose aberrant regulation has been linked to a variety of inflammatory and neoplastic diseases, and its family members including SOCS1, SOCS2 and SOCS3 were verified to be important negative regulator of JAK/Stat signalling pathway, especially for SOCS2.38 Here, CISH is linked to neoplasm.