Mechanistically, WDFY3‐AS2 promoted the expression of suppressors of cytokine signalling 2 (SOCS2) by sponging miR‐2355‐5p and further triggered the inactivation of JAK2/Stat5 signalling pathway, which resulted in the suppression of cell proliferation and invasion of ESCC cells. Here, WDFY3 is linked to esophageal squamous cell carcinoma.