We found that WDFY3‐AS2 expression in ESCA tissues was significantly lower than that in normal oesophageal tissues (P < .05) (Figure 1A and B), which was further confirmed by qRT‐PCR in 45 cases of ESCC tissues and paired normal tissues (Figure 1C). The gene discussed is WDFY3; the disease is esophageal squamous cell carcinoma.