Overall, these findings suggest that WDFY3‐AS2 is tumour suppressor lncRNA that inhibits cell proliferation and invasion by WDFY3‐AS2/miR‐2355‐5p/SOCS2/JAK2/Stat5 signalling pathway in ESCC cells (Figure 8). Here, SOCS2 is linked to esophageal squamous cell carcinoma.