As expected, dual‐flurecase reporter assay system verified that SOCS2 was a direct target gene of miR‐2355‐5p in ESCC cells, miR‐2355‐5p inhibitor significantly enhanced SOCS2 mRNA and protein levels, whereas miR‐2355‐5p mimic markedly reduced the expressions of SOCS2 mRNA and protein. Here, SOCS2 is linked to esophageal squamous cell carcinoma.