Moreover, studies have shown that KLF4 may act as an oncogene in colon cancer and breast cancer through inhibiting epithelial‐to‐mesenchymal transition (EMT) and cancer stem cell behaviors [13, 14], while the expression of KLF4 was also found to be inversely correlated with increasing tumor stage and grade in breast cancer [15]. This evidence concerns the gene KLF4 and malignant colon neoplasm.