Chang et al found that tanshinone IIA alleviated myocardial fibrosis in pressure‐overloaded rats, the mechanisms of which might be associated with the inhibition of the expression of Rho‐associated coiled‐coil protein enzyme 1 and the down‐regulation of NF‐κB, p65 and TGF‐β1.80 This evidence concerns the gene TGFB1 and Myocardial fibrosis.