SREBF1 and steatosis: In keeping with this hypothesis, a previous study in our laboratory reported that, after 14 days, AMIO-induced steatosis in HepaRG cells was associated with an increased mRNA abundance of sterol regulatory element binding transcription factor 1 (SREBF1, also known as SREBP1) and other lipogenic genes including FASN and thyroid hormone responsive (THRSP, also known as SPOT14) (Anthérieu et al. 2011).