Immunofluorescence staining of LC3 in the brain of postmortem patients showed that compared with that in the controls, the number of cells with active autophagy (LC3-positive cells among the total cells) in AD patients increased significantly by t – test (t = 4.383, P < 0.001), and the average gray level of LC3 expression in AD patients increased significantly (t = 3.397, P < 0.01). Here, MAP1LC3A is linked to Alzheimer disease.