APOE and acute disseminated encephalomyelitis: Depending on the age and clinical state, both the presence of an APOE ε4 allele and lower levels of education increase the likelihood and rate of developing symptoms of ADem, but the presence of APOE ε4 was shown to be the dominant factor (it is worth noting that studies have shown that APOE ε4 is linked to CSF Aβ1–42 accumulation [8, 53]).