After adjusting for age, sex, duration of diabetes, smoking status, hypertension, previous MI, previous PCI, previous CABG, previous stroke, BMI, LVEF, left main disease, multi-vessel disease, HbA1c, LDL-C, uric acid, hs-CRP, NT-proBNP, eGFR, statin use and insulin use, the TyG index still independently predicted the occurrence of MACE in patients with diabetes and ACS irrespective of treatment strategy. This evidence concerns the gene NPPB and hypertensive disorder.