After adjusting for age, sex, duration of diabetes, smoking status, hypertension, previous MI, previous PCI, previous CABG, previous stroke, BMI, LVEF, left main disease, multi-vessel disease, HbA1c, LDL-C, uric acid, hs-CRP, NT-proBNP, eGFR, statin use and insulin use, the TyG index still independently predicted the occurrence of MACE in patients with diabetes and ACS irrespective of treatment strategy. The gene discussed is NPPB; the disease is Stroke.