SLCO1B3 and hepatocellular carcinoma: Hence, Imai et al. [35] suggested that lt-OATP1B3 seems to be the predominant OATP1B3 isoform expressed in HCC tissue specimens, which is opposite to the pattern in lung, colon, and pancreatic cancer cells and tissues where ct-OATP1B3 is highly expressed [29].