Treatment modalities proven to have beneficial effects both on metabolic health and obesity including bariatric surgery [46, 47], sodium glucose cotransporter 2 inhibitors [48, 49] and glucagon-like polypeptide-1 receptor agonists [50, 51] might also be a preventive strategy for incident hHF. This evidence concerns the gene SLC5A2 and obesity due to melanocortin 4 receptor deficiency.