INS and decreased kidney function: Subjects with high bodyweight variability were slightly older (58.8 vs. 57.6 years), less likely to be male, had lower bodyweight (64.5 vs. 67.0 kg) and lower BMI (24.6 vs. 25.0 kg/m2), a higher proportion of hypertension and decreased renal function, and more advanced DM with higher fasting glucose and a greater number of oral anti-diabetic medication or insulin use (Table 1).