Layilin (LAYN), a transmembrane protein with homology toc-type lectin, was identified as a novel marker of T cell exhaustion and itsexpression in HCC was found to be associated with higher rates of tumour recurrence.54 Combining Smart-Seq2 and 10X Chromium approaches, Zhang and colleaguesperformed scRNA-seq of CD45+ immune cells from tumour, lymph nodes andascites to characterise macrophages and dendritic cells (DCs) in HCC.15 Lysosomal associated membrane protein 3 (LAMP3) is a DC-specific glycoproteininduced upon DC maturation after inflammatory stimulation. Here, PTPRC is linked to hepatocellular carcinoma.