HCC is a complex cellularecosystem, including clonal Tregs, clonal CD8+LAYN+ exhaustedT cells, pre-exhausted CD8+GZMK+ cells, LAMP3+ DCs,myeloid-derived suppressor cells, TAM-like macrophages and PLVAP+endothelial cells resembling the endothelial cells that inhabit the liver fibroticniche. This evidence concerns the gene LAYN and hepatocellular carcinoma.