NF1 and neurofibromatosis type 1: At this point only NF1 microdeletion patients present a more severe phenotype than that observed in classical NF1 patients, particularly in respect to the presence of early appearance of cutaneous neurofibromas, more frequent and more severe learning disabilities, somatic overgrowth, and dysmorphic facial features, among others (Koczkowska et al., 2020; Messiaen et al., 2011; Pasmant et al., 2010).