NF1 and autosomal dominant polycystic kidney disease: Although the functional consequences of NF1 mutation on ADPKD is not known, the absence of great differences on renal volume and renal function in the proband with respect to his older brother with ADPKD only and two ADPKD cohorts, is strongly suggestive of that NF1 mutation do not have a pathogenic additive effect on ADPKD.