NF1 and autosomal dominant polycystic kidney disease: In addition, in both diseases has been reported an associated high risk of intracranial aneurysms (ADPKD, 4%–17%; NF1, 9%–11%) (Erbay et al., 2004) and in case of associated mutations of the neurofibromin and polycystin‐2 proteins it is expected to have additive or synergistic intracranial aneurysms disease presentation and/or associated tumors progression.