The relationship between mGlu7 and memory is also complex, with the mGlu7-negative modulator MMPIP both impairing NOD in normal mice [58] and recently proposed as a putative antipsychotic due to its ability to reverse acute MK-801-induced hyperactivity and cognitive deficits in mouse NOD and rat spatial delayed alternation tests [56]. This evidence concerns the gene GRM7 and Cognitive impairment.