As shown in Fig. 3, the expression of all three α-subunits is higher in the nucleus of low-grade serous ovarian cancer cases with a trend to significance in the general THRα (p = 0.078), no significance for THRα1 and a significantly higher THRα2 expression in low-grade serous cancer cases compared to high-grade subtype (the receiver operating characteristic curve (ROC) analyses were performed to calculate the optimal cut-off values between low and high expression of the different THRs). The gene discussed is THRA; the disease is ovarian serous adenocarcinoma.